Correlative Sciences

Gene expression analysis may help minimize surgery for thyroid nodules

Alexander and colleagues reported the results of a prospective, multicenter study of 3789 patients who underwent fine-needle aspiration (FNA) of thyroid nodules (New England Journal of Medicine, August 23, 2012).   The goal of FNA is to identify patients who have thyroid cancer and require thyroidectomy.  Unfortunately FNA is not always diagnostic, and some nodules are pathologically indeterminate, meaning that cancer can not be excluded.  Currently many of these patients have thyroid surgery, though the majority of patients with indeterminate results on FNA do not have thyroid cancer. ... Continue reading


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