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Thyroid cancer is the most common endocrine neoplasm and the incidence continues to rise worldwide. For many patients, standard therapy is effective for achieving long-term survival. Patients who develop aggressive or recurrent diseases represent a considerable therapeutic challenge, thus the search for novel treatment strategies for these difficult cases remains a key component of ITOG’s mission.

ITOG has partnered with pharmaceutical companies and other cancer groups in a concerted effort to make headway in finding a path forward for these aggressive tumor types. Below, please find a list of ITOG’s active and upcoming clinical trials.  


Clinical  Identifier (Click for more information)      ITOG Clinical  Trials     
 NCT03914300   Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated  Thyroid Cancer    
 NCT02973997   Combination Immunotherapy with Multikinase Inhibitor (MKI) in Progressive, Radiodine-resistant Differentiated  Thyroid Cancers    
 NCT02393690   Iodine I-131 With or Without Selumetinib in Treating Patients with Recurrent or Metastatic Thyroid Cancer    
 NCT03157128   Phase 1/2 Study of LOXO-292 in Patients with Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and  Medullary Thyroid Cancer
 NCT02143726   Randomized Phase II Study of Sorafenib with or without Everolimus in Patients with Radioactive Iodine Refractory Hürthle Cell Thyroid Cancer
 NCT02657369   An Open-Label, Single-Arm, Multicenter, Phase 2 Trial of Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC)    
NCT01811212   Phase II Study of Cabozantinib in Patients with Radioiodine-Refractory Differentiated Thyroid Cancer Who Progressed on Prior VEGFR-Targeted Therapy


There are many Thyroid clinical trials being conducted all across the globe.   Please use the following resources to find one near you.  


Helping People Connect with Clinical Trials.  First launched in 1994, the Clinical Trials Listing Service assists patients in finding and volunteering for clinical trials.  Today, CenterWatch has the largest online database of industry-sponsored global clinical trials actively seeking volunteers.


 Accurate, up-to-date, comprehensive cancer information from the U.S. government's principal agency for cancer research.




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International Thyroid Oncology Group

5166 Commercial Drive

Yorkville, New York 13495

Our mission
To catalyze a cure for the most challenging thyroid cancers through the collaborative efforts of our unique multidisciplinary team of leading physicians, scientists, and advocates to design, coordinate, and prioritize state-of-the-art clinical trials and correlative science.